Stem Cells Could Treat Brittle Bone Disease In Children

Bone-Marrow Diseases and Anemia

“It will help us to understand what it is that leads to such a marked effect after a single transplant of stem cells, so that this can be harnessed to improve the results of stem cell therapy in repairing adult tissues and degenerative conditions,” he said. “Our work suggests that, in the future, it could be possible to take stem cells from an unborn baby carrying the abnormal OI gene, manipulate them to correct the errant gene, and then put them back into the foetus to allow it to develop properly. “We only need to collect 100 or 200 microlitres of blood from the foetus, which is a tiny amount, less than a fifth of a millilitre of blood. From this tiny sample we can grow all that we need to provide the potential treatment. “However, with further work we should be able to gain the stem cells we need from amniotic fluid or the placenta; thereby removing any potential risk of drawing foetal blood.” Professor Fisk said a two thirds reduction in fractures was “extraordinary”. But he said the treatment was not a cure.
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Bone disease forces dual-purpose star Countrywide Flame into retirement

Fighting spirit: Countrywide Flame on his way to winning the Grade One Fighting Fifth Hurdle at Newcastle in 2012

Winner of the Triumph Hurdle and the Fighting Fifth in 2012, the five-year-old went on to run a fantastic race to finish third behind Hurricane Fly in last season’s Champion Hurdle at the Cheltenham Festival. Fighting spirit: Countrywide Flame on his way to winning the Grade One Fighting Fifth Hurdle at Newcastle in 2012 Blow: Countrywide Flame, pictured here before the Champion Hurdle at Cheltenham in March, has been forced to retire because of a degenerative bone disease Runner-up in last year’s Cesarewitch, Countrywide Flame has not been seen since finishing a close-up fifth in the Chester Cup in May and the ten-time winner was ruled out for the jumps season in October with a leg injury, but further deterioration has led to connections drawing stumps altogether. Quinn said: ‘Unfortunately he’s got bone degeneration in his two hind joints and while we can keep him comfortable, there’s no coming back from that I’m afraid. ‘The initial injury wasn’t coming right as fast as we expected, so we looked into it and investigated it further and this came up, unfortunately. ‘He’s been a horse and a half.’
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Too much tea causes unusual bone disease

(اردو) ریاستی اسمبلیوں کے انتخابی نتائج اور کم ہوتی مسلمانوں کی نمائندگی : تیشہ فکر عابد انور

The breakthrough drug is Soliris (eculizumab), which helps control PNH, but it is not curative, says Kassim. A recent study showed that hemoglobin levels stabilized in almost 50 percent of people with PNH who received treatment with Soliris, compared with none of the patients who did not receive Soliris. Patients who received Soliris also did not need as many red blood cell transfusions as those who didn’t take the drug. While the results are promising, Kassim says researchers have not yet found a cure for PNH. Without a bone marrow transplant, the PNH patient will eventually die from complications. Leukemia can be treated with chemotherapy or radiation. If leukemia is unresponsive to such treatment, a bone marrow transplant may also be an option.
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Best Christmas gift ever: 9-year-old boy donates bone marrow to save his 5-year-old brothers life

X-rays revealed areas of very dense bone on the spinal vertebrae and calcifications of ligaments in her arm, said study researcher Dr. Sudhaker D. Rao, a physician at Henry Ford Hospital who specializes in endocrinology and bone and mineral metabolism. The researchers suspected the woman had skeletal fluorosis, a bone disease caused by consuming too much fluoride, a mineral found in tea as well as drinking water. According to researchers, the patients blood levels of fluoride were four times higher than what would be considered normal.
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Guide to Bone Health and Disease in Cystic Fibrosis

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For the source article please follow this weblink – http://jcem.endojournals.org/content/90/3/1888.full

Lovebirds reunited: Peter Crouch and Strictly Come Dancing champion Abbey Clancy walk down the street hand-in-hand

The boys parents, Louise, 32, and Paul, 38, of Waterlooville, Hampshire, have been told there is an 80 per cent chance the transplant will cure their youngest son. Sam Merrick (pictured), five, has been given a life-saving bone marrow transplant thanks to his brother, Kiran, nine, who agreed to donate his bone marrow for the procedure Mother-of-four, Mrs Merrick said: We were all tested but Kiran was the one who had a 10 out of 10 match, which is the best match there could be.Kiran told us he was scared so we talked to him in depth about it and said that if he didnt want to do it we would understand. But he said he wanted to help Sam and started having numerous tests.It was hard work with Sam and Kiran both in hospital but Kiran has done us both proud.When Sam is ill now he always offers to give him more bone marrow to help his brother. Sams disease has meant hes caught more than the usual amount of childhood viruses and infections, with the severity much worse. Sam (front right) was born prematurely at just 26 weeks. He has a weak immune system and has had so many viruses that his lungs are full of scar tissue. He is pictured with his brothers Kiran (back right), Liam, 7, (front left) and Jordan, 13, (back left) Sam had such a weak immune system he had to be protected from germs as much as possible.
Link: http://www.ynaija.com/best-christmas-gift-ever-9-year-old-boy-donates-bone-marrow-to-save-his-5-year-old-brothers-life/

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