Metabolic syndrome not a good predictor of death
But other work has suggested that genetic variants near IRS1 are associated with features of the metabolic syndrome. So to explore whether these SNPs modulate the effects of various diets on metabolic syndrome, Qi and colleagues genotyped the 738 overweight and obese patients enrolled in the trial for two variants: rs1522813 and rs2943641. Among patients with the rs1522813 genotype, those on a high-fat diet had higher reversion rates of metabolic syndrome than those on a low-fat diet at 2 years (45.9% versus 28.1%, P=0.04). Patients without this variant had no difference in reversion rates whether their diet had a high or low fat content. In regression analyses, the high-fat diet was also significantly associated with reversion of metabolic syndrome among those with the variant (OR 2.88, 95% CI 1.25 to 6.67, P=0.04). On the other hand, the variant rs2943641 didn’t modulate dietary effects on metabolic syndrome.
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Dariush Mozaffarian, of Harvard School of Public Health, Boston, Massachusetts, and colleagues note in the latest issue of the Archives of Internal Medicine. To clarify the situation, they assessed relationships of metabolic syndrome and individual metabolic syndrome components with death among 4,258 elderly adults participating in a heart health study. At the outset, 31 percent of men and 38 percent of women had metabolic syndrome. A total of 2,116 deaths occurred during 15 years of follow-up. Results showed that those with metabolic syndrome had a 22 percent higher risk of dying compared to those without metabolic syndrome. But the higher mortality risk associated with metabolic syndrome was confined to individuals who had elevated fasting blood sugar levels or hypertension as one of the criteria, according to the team. Patients with metabolic syndrome but no elevated blood sugar or hypertension did not have a higher risk.
What is metabolic syndrome? What causes metabolic syndrome?
NEW YORK (Reuters Health) – There is no end in sight for the increasing rate of metabolic syndrome among Americans, with the prevalence growing among young adults as well, a new study finds. Metabolic syndrome refers to a collection of risk factors for type 2 diabetes and heart disease that includes abdominal obesity (belly fat), high blood pressure, elevated blood sugar, low HDL (“good”) cholesterol, and high triglycerides (another type of blood fat). The main concern with this continuing rise is that it forecasts a similar increase in the rate of type 2 diabetes, according to researcher Dr. Gary Liguori, an assistant professor of health, nutrition and exercise sciences at North Dakota State University in Fargo. The new study found that 34 percent of U.S. adults in government health surveys conducted between 1999 and 2006 had metabolic syndrome — up from 29 percent in similar surveys done between 1988 and 1994. The researchers estimate that about 50 million U.S.
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Metabolic syndrome continues to climb in the U.S.
In a study published by the Institute of Health, it was noted that “although weight loss is an effective treatment for metabolic syndrome, standard health insurance rarely covers intensive behavioral treatment programs.”, that focus on behavioral change strategies to promote weight loss. They also do not routinely cover the cost of “diet” programs. This suggests that in addition to offering financial incentives for voluntarily participating in a MetS program, offering additional financial incentives for weight management, to employees who voluntarily elect to be screened for MetS, may increase the interest in both screening and participating in weight management programs. As noted in a article posted in commonhealth.wbur.org, ” Federal law generally prohibits plans from charging different premiums to different employees based on a health factor. However, there is an exception for bona fide wellness programs. These programs allow an employer to vary premiums up to 20% based on a health factor (such as cholesterol and weight) but only if the employer offers a reasonable alternative to those for whom it is unreasonably difficult to meet the standard.” Including financial incentives in the form of weight loss programs for individuals who do not qualify for the financial MetS incentive will help meet this requirement. As pointed out in a previous article “, more employers are screening for MetS, and as the embrace screening programs like MetS they are getting more creative in offering incentives.
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Together, diet and exercise improve risk factors more than diet alone. Other lifestyle management factors include smoking cessation and limiting alcohol consumption. Diet. Changes in dietary habits are important in the treatment of metabolic syndrome. According to the AHA, treatment of insulin resistance is necessary to achieve the greatest benefit for modifying metabolic risk factors. In general, the best way to treat insulin resistance is through weight loss and increased physical activity.
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Consider Metabolic Screening, even if you think you won’t pass
The person’s body is unable to control blood sugar levels, also known as insulin resistance. Abnormal blood cholesterol – low levels of HDL, also known as high-density lipoprotein or “good cholesterol “, less than 40mg/dL (1.04mmol/L) High blood triglycerides – triglycerides are a form of circulating fats. Levels of at least 150mg/dL or 1.7mmol/L. People with metabolic syndrome also have a higher risk of deep vein thrombosis , and tend to develop inflammation . What are the causes of metabolic syndrome? We know what conditions are associated with metabolic syndrome, but nobody is exactly sure what its causes are. In all cases, there is a close association with “insulin resistance”.
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