Bone-marrow Diseases And Anemia

A recent study showed that hemoglobin levels stabilized in almost 50 percent of people with PNH who received treatment with Soliris, compared with none of the patients who did not receive Soliris. Patients who received Soliris also did not need as many red blood cell transfusions as those who didn’t take the drug. While the results are promising, Kassim says researchers have not yet found a cure for PNH. Without a bone marrow transplant, the PNH patient will eventually die from complications. Leukemia can be treated with chemotherapy or radiation. If leukemia is unresponsive to such treatment, a bone marrow transplant may also be an option. Bone-Marrow Disease Anemia and the Link to Blood Cancer The prognosis for bone marrow disease is not encouraging myelodysplastic syndromes, aplastic anemia, and paroxysmal nocturnal hemoglobinuriacan each progress to blood cancer. The rate of progression depends on the type of defect in the bone marrow, says Kassim.
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One in five women suffer three fractures before bone disease is spotted: Late diagnosis increases risk of serious harm or death

Chappard, A. Maghraoui, C. C. Gluer, D. Kendler, N. Napoli, A. Papaioannou, D.
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Fracture Prevention in Cancer-Associated Bone Disease

Skeletal fluorosis is endemic in regions of the world with naturally high levels of fluoride in drinking water, including some parts of India and China, but is rare in Europe and North America. (Low levels of fluoride are added to drinking water in the United States to prevent cavities , but aren’t high enough to cause fluorosis.) Rao said the patient was originally referred to him because her doctors suspected she had cancer, which can also show up on an X-ray as areas of dense bone. But because Rao had seen cases of skeletal fluorosis in his native India, “I was able to recognize it immediately,” he said. Excess fluoride is typically eliminated from the body by the kidneys, Rao said. But if one consumes a lot of it, as this patient did through tea drinking, over time, the fluoride forms crystal deposits on bone, Rao said. A few other cases of skeletal fluorosis caused by tea drinking have been reported in the United States.
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Causes of Brittle Bone Disease

In Paget’s disease, the bone remodeling process is disregulated. New bone is placed where it is not needed, and old bone is removed where it is needed. This disregulation can distort the normal skeletal architecture. The excessive breakdown and formation of bone tissue that occurs with Paget’s disease can cause bone to weaken, resulting in bone pain, arthritis , deformities, and fractures . Paget’s disease is more common in certain geographical locations, specifically England, Western Europe, and the United States. It is very uncommon in Scandinavia, China, and India. Paget’s disease is most commonly diagnosed in the sixth decade, and increases in prevalence as age increases.
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What Is Paget’s Disease Of Bone? What Causes Paget’s Disease?

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Hip fractures lead to 1,150 deaths every month. Baby becomes youngest organ donor in Britain after dying at five weeks as kidneys are given to 22-year-old woman But only a third of health trusts run fracture-liaison services to act on the first break and help prevent it happening again, according to the Royal College of Physicians. Dr Jonathan Treml, RCP associate director for falls and bone health, said that, after changes to GP contracts last year, doctors pay now partly depends on checking for the disease among patients. They must ensure patients who break a bone are given a referral to a fracture clinic for diagnosis and treatment. Part of the job: RCP associate director Dr Treml says it is a GP’s job to check for the disease since contract changes Dr Treml added: Im optimistic this will eventually make a difference to preventive work. Some 89,000 hip fractures a year are linked to osteoporosis, which cost the UK 6million a day in health and social costs.
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Too Much Tea Causes Unusual Bone Disease

The bones are never able to strengthen because the bad collagen fiber binds and consumes any existing healthy collagen fibers.The process is cyclical in a growing child and prevents new healthy and strong bones from forming. The result is increased fractures and breakage during youth. However, this process abates mildly after puberty when the process of bone growth slows. Genetics According to the National Human Genome Research Institute, most types of osteogenesis imperfecta result from an inherited autosomal dominant pattern. This means that if a child is born to a parent with a dominant mutation there is a 50 percent chance of the bone disease passing to the child. On the other hand, the National Institute of Arthritis Musculoskeletal and Skin Diseases explains that approximately 15 percent of cases of inherited osteogenesis imperfecta result from recessive mutation.
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