Gene Altering Lotion May Treat Skin Diseases

Amy Paller, chair of dermatology and professor of pediatrics at Northwestern University Feinberg School of Medicine . But the difficulty among researchers has been creating a gene-altering topical agent that can successfully penetrate the skin to specifically treat genetic skin diseases. “The problem is that our skin is a formidable barrier,” Paller said. “Genetic material can’t get through the skin through regular means.” Using nanotechnology, the researchers packaged gene-altering structures on top of tiny particles of gold designed to target epidermal growth factor receptor, a genetic marker associated with many types of skin cancers. The structure is designed to sneak through the skin and latch onto targets underneath without eliciting an immune response.
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Autoimmune Bullous Skin Diseases

This is the third setback for Rigel this year and comes about two months after the company stopped the development of its asthma drug, which failed a mid-stage trial. British drugmaker AstraZeneca stopped developing Rigel’s rheumatoid arthritis treatment, fostamatinib, in June, which it licensed from Rigel in 2010. Rigel said on Thursday the skin disorder drug, codenamed R333, failed to reduce the redness and roughness of flaky skin in patients with discoid lupus, a disease characterized by sores that can lead to scarring and hair loss. Chief Executive Officer James Gower said the company would now focus on its drugs to treat dry-eye disease and a blood disorder, both of which are currently in mid-stage studies. Rigel also said it met with the U.S. Food and Drug Administration to discuss fostamatimib as a treatment for a blood disorder, and would start two late-stage studies of the drug in the first half of 2014. (Reporting By Vrinda Manocha in Bangalore; Editing by Saumyadeb Chakrabarty and Savio D’Souza)
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Implant Helps Those With Skin Diseases, and Gives Them a Tan Too

PHOTO: Robert Saupe visiting Texas in 2009. Because of his condition, his skin must be covered up from head to to, even in temperatures well above 90 degrees, as they were during this trip.

The autoimmune bullous disorders include: Pemphigus and Pemphigoid disorders IGA – mediated disorders PEMPHIGUS AND PEMPHIGOID DISORDERS Pemphigus disorders and pemphigoid disorders (bullous pemphigoid, cicatrical pemphigoid) are considered prototypic bullous disorders because of their well-defined autoantibody-mediated development or pathogenesis. The three pemphigus disorders target desmoglein protein, and the pemphigoid disorders target Type XVII collagen and bullous pemphigoid (BP) antigen 2, BP antigen 180, BP antigen 230, and laminin 5. The end result is a loss of the skin’s architecture. In the absence of a well-organized viable skin composition, blisters and erosions form craters between the tissues cells. Pemphigus disorders may present or worsen during pregnancy, especially in the first and second trimesters.
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Rigel to drop skin disease drug after trial failure

The majority of moles are small, dark brown spots on the skin, though they can appear in a wide variety of colors, shapes and sizes. Psoriasis Approximately 2 percent of the United States population has psoriasis, an inflammatory skin disease characterized by red, scaly and itchy patches of skin, according to the Cleveland Clinic. Psoriasis can occur at any age, but most commonly arises in the 30s. The patches are most often found on the elbows, knees, legs, scalp, face, palms, lower back and soles of the feet. Rosacea Rosacea, a chronic, inflammatory skin disease in adults, is characterized by frequent redness or flushing in the face. Along with facial flushing, rosacea can produce small bumps and pustules that often resemble other skin conditions such as acne. There is no cure for rosacea, but treatment options do exist for the symptoms, which most often occur in a cyclic pattern.
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10 Most Common Skin Diseases

Skin is prone to a host of conditions and diseases.

He has a condition called erythropoietic protoporphyria, or EPP, a rare disease that causes extreme sensitivity to sunlight and certain types of artificial light. “I don’t go outside without having a long-sleeve shirt on, a hat, a bandanna and gloves,” he said. EPP is caused by elevated levels of porphyrins, the chemicals responsible for the synthesis of hemoglobin, the protein that carries oxygen in the blood, producing a toxic reaction to the sun. After the skin is exposed for only a short time, it can turn extremely red and develop symptoms of intense itching, swelling and burning. EPP is especially challenging for Saupe in the summer, since he works outdoors as an excavator. “On the hot days wearing all that — it’s exhausting,” said Saupe, 45.
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